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Example:10.1021/acsami.1c06204 or Chem. Rev., 2007, 107, 2411-2502
Drug Sensitivity Profile of Fungi Isolated from Onychomycosis Patients and Evaluation of Squalene Epoxidase Mutation in One Terbinafine-Resistant Trichophyton mentagrophytes Species
Microbial Drug Resistance  (IF3.431),  Pub Date : 2021-07-23, DOI: 10.1089/mdr.2020.0572
Alireza Firooz, Maryam Daneshpazhooh, Ensieh Lotfali, Mahshid Sharzad Kavkani, Zeinab Ghasemi, Ali Khamesipoor, Mansour Nassiri Kashani, Akram Miramin Mohammadi, Seyed Ebrahim Skandari, Saman Ahmad Nasrollahi, Azam Fattahi

Background: The resistance to treatment of onychomycosis is increasingly reported. The present study aimed to assess the antifungal activity of itraconazole, terbinafine, luliconazole, and efinaconazole against dermatophytes, molds, and also yeast isolated from patients with onychomycosis. Furthermore, the mechanism of resistance to terbinafine in resistant Trichophyton mentagrophytes species was evaluated using the squalene epoxidase (SQLE) gene sequence.