The field of entrepreneurship education (EE) is still new, but it is growing very quickly, with potential to strengthen business education, innovation and economies. Only recently has attention been paid to the quality of the research being produced. Building on previous reviews, this paper uses systematic review methodology to search and grade the most recent literature in EE in higher education. This process finds that some high-quality research is being done but much of the field is held back by methodological limitations, including inadequate description of EE programs, heavy reliance on correlational survey designs, common self-selection bias and a paucity of studies able to establish causal effects on entrepreneurial outcomes. A small number (10) of high-quality studies provide evidence of the effectiveness of experiential programs, within university extracurricular programs; and provide a range of findings to inform current EE practice. Gaps for future research and methodological possibilities are outlined, so that EE research can address current weaknesses and fulfil its potential to inform EE, enabling effective teaching and learning and the prospect of long-term educational, economic and social outcomes.