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B7-H6 as a Diagnostic Biomarker for Cervical Squamous Cell Carcinoma
Genetic Testing and Molecular Biomarkers  (IF1.795),  Pub Date : 2021-07-19, DOI: 10.1089/gtmb.2020.0313
Xuejing Liu, Ruimeng Guo, Yanying Xu

Background:B7-H6, a newly discovered member of the immunoglobulin superfamily, exerts antitumor effects by binding to NKP30 receptor on natural killer cells; it has important clinical implications. Cell surface ectodomain shedding of B7-H6 generates soluble B7-H6 (sB7-H6), which is highly expressed and serves as a valuable biomarker in multiple tumors, but the clinical significance and diagnostic value of B7-H6 in cervical squamous cell carcinoma (CSCC) remains unclear.