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The decreasing prevalence of the thyroid ima artery: A systematic review and machine learning assisted meta-analysis
Annals of Anatomy  (IF2.698),  Pub Date : 2021-07-12, DOI: 10.1016/j.aanat.2021.151803
Laphatrada Yurasakpong, Chanin Nantasenamat, Sirorat Janta, Pinthusorn Eiamratchanee, James Coey, Arada Chaiyamoon, Nutmethee Kruepunga, Thanyaporn Senarai, Martin Franz Langer, Krai Meemon, Athikhun Suwannakhan

Introduction

Thyroid ima artery is a variant artery found on the anterior surface of the trachea. The aim of this meta-analysis was to obtain pooled prevalence data of the thyroid ima artery and discuss its clinical importance especially for tracheostomy.

Methods

A systematic literature search was performed through five electronic databases until May 2021. A set of inclusion and exclusion criteria based on AQUA guidelines were used to select relevant studies. Meta-analysis, subgroup analyses, meta-regression, and tests for publication bias were performed. Factors that influence the prevalence of the thyroid ima artery were detected using simple and interpretable machine learning (linear regression and K means).

Results

Thirty-six studies with a total of 4335 subjects met the inclusion criteria. The prevalence of the thyroid ima artery was 3.8% (95% CI: 0.027−0.049, I2 = 56.2%). Machine learning identified age, region and year of publication as potential covariates. Subgroup analysis showed that the prevalence of the thyroid ima artery was 4.5 times higher in fetuses (14.8%) than adults (3.3%) (z = −6.76, p < 0.01). There was a significant negative correlation between the adult prevalence of the thyroid ima artery and the year of publication (Pearson’s r = −0.354, p = 0.040) thereby suggesting a decline in thyroid ima artery prevalence over time. This artery, if present, may originate from the brachiocephalic trunk (74%), right common carotid artery (9.6%), arch of aorta (7.7%), right internal thoracic artery (4.8%), left common carotid artery (1.9%) and left internal thoracic artery (1.9%).

Conclusion

In addition to evidence-based synthesis of the thyroid ima artery, this study is the first ever study to report the decreasing prevalence over time of a human body structure in the postnatal life. Knowledge of the thyroid ima artery is of vital importance for surgeons to avoid accidental hemorrhage during tracheostomy.