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Medicinal and Biological Significance of Phenoxazine Derivatives
Mini-Reviews in Medicinal Chemistry  (IF3.862),  Pub Date : 2021-06-30, DOI: 10.2174/1389557520666201214102151
Shruti, Shukla

Since 1887, phenoxazine derivatives have attracted the attention of chemists due to their versatile utility, industrially and pharmacologically. Literature is found abundant with various pharmacological activities of phenoxazine derivatives like antitumor, anticancer, antifungal, antibacterial, anti-inflammatory, anti-diabetic, anti-viral, anti-malarial, anti-depressant, analgesic and many other drug resistance reversal activities. This review covers a detailed overview of the pharmacological application of phenoxazine nucleus, its chemistry and reactivity, and also illustrating the incorporation of different groups at different positions enhancing its biological application, besides some synthetic procedures.