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Plasticity of the human preimplantation embryo: developmental dogmas, variations on themes and self-correction
Human Reproduction Update  (IF15.61),  Pub Date : 2021-06-15, DOI: 10.1093/humupd/dmab016
Giovanni Coticchio, Amy Barrie, Cristina Lagalla, Andrea Borini, Simon Fishel, Darren Griffin, Alison Campbell

IVF for the treatment of infertility offers unique opportunities to observe human preimplantation development. Progress in time-lapse technology (TLT) and preimplantation genetic testing (PGT) has greatly expanded our knowledge of developmental patterns leading to a healthy pregnancy or developmental failure. These technologies have also revealed unsuspected plastic properties of the preimplantation embryo, at macromolecular, cellular and multicellular levels.