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Targeting the adipose tissue to protect the heart
Nature Reviews Cardiology  (IF32.419),  Pub Date : 2021-06-15, DOI: 10.1038/s41569-021-00588-3
Irene Fernández-Ruiz

Treatment with atglistatin, an inhibitor of adipose triglyceride lipase (ATGL) activity, has cardioprotective effects against catecholamine-induced cardiac damage in mice, according to a new study. Atglistatin inhibited adipose ATGL activity but had no effect on cardiac ATGL, indicating that its cardioprotective effects are mediated by non-cardiac actions.