Example：10.1021/acsami.1c06204 or Chem. Rev., 2007, 107, 2411-2502
Unmasking latent thioesters under hydrophobic-compatible conditions Journal of Peptide Science (IF1.905), Pub Date : 2021-06-13, DOI: 10.1002/psc.3358 Wade S. Perkins, Ryan T. Davison, Gregory B. Shelkey, Vernon E. Lawson, Grace E. Hutton, Justin S. Miller
Hydrophobic latent C-terminal thioesters were converted into thioesters, and were also coupled with cysteine in one-pot reactions, using conditions generally compatible with hydrophobic materials. The reaction conditions (ethanethiol and triethylamine in a mixture of DMF and THF) are compatible with acid-labile protecting groups (Boc/t-Bu) that are standard in Fmoc peptide synthesis.