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An antiviral trap made of protein nanofibrils and iron oxyhydroxide nanoparticles
Nature Nanotechnology  (IF39.213),  Pub Date : 2021-06-03, DOI: 10.1038/s41565-021-00920-5
Archana Palika, Antonius Armanious, Akram Rahimi, Chiara Medaglia, Matteo Gasbarri, Stephan Handschin, Antonella Rossi, Marie O. Pohl, Idoia Busnadiego, Christian Gübeli, Ravi B. Anjanappa, Sreenath Bolisetty, Mohammad Peydayesh, Silke Stertz, Benjamin G. Hale, Caroline Tapparel, Francesco Stellacci, Raffaele Mezzenga

Minimizing the spread of viruses in the environment is the first defence line when fighting outbreaks and pandemics, but the current COVID-19 pandemic demonstrates how difficult this is on a global scale, particularly in a sustainable and environmentally friendly way. Here we introduce and develop a sustainable and biodegradable antiviral filtration membrane composed of amyloid nanofibrils made from food-grade milk proteins and iron oxyhydroxide nanoparticles synthesized in situ from iron salts by simple pH tuning. Thus, all the membrane components are made of environmentally friendly, non-toxic and widely available materials. The membrane has outstanding efficacy against a broad range of viruses, which include enveloped, non-enveloped, airborne and waterborne viruses, such as SARS-CoV-2, H1N1 (the influenza A virus strain responsible for the swine flu pandemic in 2009) and enterovirus 71 (a non-enveloped virus resistant to harsh conditions, such as highly acidic pH), which highlights a possible role in fighting the current and future viral outbreaks and pandemics.