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Deep brain stimulation: Challenges at the tissue-electrode interface and current solutions
Biotechnology Progress  (IF2.681),  Pub Date : 2021-05-30, DOI: 10.1002/btpr.3179
Emily Kolaya, Bonnie L. Firestein

Deep brain stimulation (DBS) is used to treat the motor symptoms of Parkinson's disease patients by stimulating the subthalamic nucleus. However, optimization of DBS is still needed since the performance of the neural electrodes is limited by the body's response to the implant. This review discusses the issues with DBS, such as placement of electrodes, foreign body response, and electrode degradation. The current solutions to these technical issues include modifications to electrode material, coatings, and geometry.