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Association of CST3 Gene with Its Protein: Cystatin C in Health and Severe Periodontal Disease
Genetic Testing and Molecular Biomarkers  (IF1.795),  Pub Date : 2021-06-16, DOI: 10.1089/gtmb.2021.0049
Jeneffar Roselin Christopher, Deepa Ponnaiyan, Harinath Parthasarathy, Anupama Tadepalli

Background: Cystatin C (CSTC), a cysteine protease inhibitor, is found to be elevated in periodontal disease in an attempt to counterbalance the proteolytic enzymes and increased osteoclastic activity. Evidence on CSTC levels in periodontal health and disease has reported contradicting results, making its role as a biomarker in periodontal pathogenesis inconclusive.