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Long Intergenic Nonprotein Coding RNA 173 Inhibits Tumor Growth and Promotes Apoptosis by Repressing Sphingosine Kinase 1 Protein Expression in Pancreatic Cancer
DNA and Cell Biology  (IF3.311),  Pub Date : 2021-06-08, DOI: 10.1089/dna.2020.6103
Qian Li, Xingxing Li, Xiaojun Yang, Bin Zhang, Yuqing Gu, Guangliang Gu, Jiageng Xiong, Yanan Li, Zhuyin Qian

Pancreatic cancer is a common malignant tumor worldwide. Extensive studies have been conducted on the functional role of long noncoding RNAs in pancreatic cancer. In this study, long intergenic nonprotein coding RNA 173 (LINC00173) was highly expressed in pancreatic cancer tissues. In vitro functional experiments showed that LINC00173 overexpression inhibited the proliferation and invasion of pancreatic cancer cells and promoted cell apoptosis in MIA PaCa-2 and PANC-1 cells.