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Example:10.1021/acsami.1c06204 or Chem. Rev., 2007, 107, 2411-2502
Kaempferol attenuates spinal cord injury by interfering inflammatory and oxidative stress by targeting the p53 protein: a molecular docking analysis
Molecular & Cellular Toxicology  (IF1.08),  Pub Date : 2021-05-07, DOI: 10.1007/s13273-021-00132-x
Lu Chen, Kai Cao, Yurong Gu, Chao Luo, Wei Mao, Weijun Zhou, Jinwei Zhu, Huying Zhang

Background

Kaempferol (KMF) is a flavone reported to have anti-oxidant and anti-inflammatory activity.

Objective

The present study screened the effect of KMF in the animal model of spinal cord injury (SCI).

Results

KMF caused a significant inhibition of spinal cord injury mediated oxidative stress and also suppressed the inflammatory reactions. The treatment of KMF also inhibited the levels of p53, TGF-β1 and COX-2 whereas a significant elevation in Bcl-2/Bax ratio was observed after the rats were treated with KMF. The in silico docking analysis suggested potential binding of KMF having lower energy with p53 confirming the potential target of KMF.

Conclusion

The treatment of KMF exerted neuroprotective effect by improving the anti-oxidant status and inflammatory response. The significant spinal cord injury protective effect of KMF in rats was attributed by targeting p53 and Bcl-2/Bax ratio.