Find Paper, Faster
Example:10.1021/acsami.1c06204 or Chem. Rev., 2007, 107, 2411-2502
Applications and Functions of γ-Poly-Glutamic Acid and its Derivatives in Medicine
Current Pharmaceutical Biotechnology  (IF2.837),  Pub Date : 2021-08-31, DOI: 10.2174/1389201021999201118161155
Guoliang, Wang

Background: γ-Poly-Glutamic Acid (γ-PGA) is a naturally occurring homo-polyamide produced by various strains of Bacillus. It is made from repeating units of L-glutamic acid, D-glutamic acid, or both connected through amide linkages between α-amino and γ-carboxylic acid groups. As a biopolymer substance, the attractive properties of γ-PGA are that it is water-soluble, biodegradable, biocompatible, non-toxic, non-immunogenic, and edible. Therefore, it can be used as a green and environmentally friendly biological material.

Methods: The review concentrates on the reports revealing the functions and potential use of γ-PGA and its derivatives in medicine.

Results & Discussion: γ-PGA is described to possess several properties that may be exploited in medicine. The biopolymer reportedly has been successfully applied not only as a metal chelator, drug carrier/ deliverer, and gene vector, but also used safely as a vaccine adjuvant, tissue engineering material, and contrast agent.

Conclusion: γ-PGA could be potentially considered as a potential biomedical material in the field of medicine.