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Coalition Forces of Immunologists and Oncologists for Defeating Cancer
Immune Network  (IF6.303),  Pub Date : 2020-01-01, DOI: 10.4110/in.2020.20.e1
Eui-Cheol Shin There has been a long journey in the effort to harness the immune system for the treatment of cancer since Coley's toxin was first used to treat cancer 120 years ago. However, almost all efforts failed to improve patient outcomes. Meanwhile, the concept of cancer immunosurveillance and immunoediting has been established (1), and T cells have been considered major players in the immune responses to cancer. Moreover, immunologists have found that tumor antigen-specific T cells are largely ‘exhausted’ in both murine and human tumors (2).