Example：10.1021/acsami.1c06204 or Chem. Rev., 2007, 107, 2411-2502
DPYD c.1905 + 1G>A Promotes Fluoropyrimidine-Induced Anemia, a Prognostic Factor in Disease-Free Survival, in Colorectal Cancer Genetic Testing and Molecular Biomarkers (IF1.795), Pub Date : 2021-04-19, DOI: 10.1089/gtmb.2020.0285 Adem Deligonul, Secil Aksoy, Gulcin Tezcan, Berrin Tunca, Ozkan Kanat, Erdem Cubukcu, Tuncay Yilmazlar, Ersin Ozturk, Unal Egeli, Gulsah Cecener, Adem Alemdar, Turkkan Evrensel
Background and Aim: In 10–30% of colorectal cancer (CRC) patients, toxic reactions occur after fluoropyrimidine-based chemotherapy. A dihydropyridine dehydrogenase (DPYD) gene variant, c.1905 + 1G>A, leads to intolerance to fluoropyrimidines. Due to the low frequency of this variant in many populations, the prevalence of fluoropyrimidine-induced hematologic side effects in CRC patients with the c.1905 + 1G>A variant is unclear. In this study, we investigated the prevalence of the DPYD c.1905 + 1 variants in a Turkish CRC cohort and the potential effects of these variants on fluoropyrimidine-induced hematologic side effects.