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Example:10.1021/acsami.1c06204 or Chem. Rev., 2007, 107, 2411-2502
Genotypic Analyses of the Sclerostin rs851056 and Dickkopf rs1569198 Polymorphisms in Mexican-Mestizo Postmenopausal Osteoporosis: A Case–Control Study
Genetic Testing and Molecular Biomarkers  (IF1.795),  Pub Date : 2021-03-17, DOI: 10.1089/gtmb.2020.0199
Maria L. Vazquez-Villegas, Norma A. Rodriguez-Jimenez, Betsabe Contreras-Haro, Jose C. Vasquez-Jimenez, Edsaul E. Perez-Guerrero, Maria-Cristina Moran-Moguel, Esther N. Sánchez-Rodríguez, Alejandra Villagómez-Vega, Ismael Nuño-Arana, Itzel N. Becerra-Alvarado, Edy D. Rubio-Arellano, Cesar A. Nava-Valdivia, Juan M. Ponce-Guarneros, Nicte S. Fajardo-Robledo, Arnulfo H. Nava-Zavala, Laura Gonzalez-Lopez, Ana M. Saldaña-Cruz

Background: The Wnt/β catenin pathway promotes bone mineralization stimulating proliferation, differentiation, and survival of osteoblasts; it also inhibits osteoclast differentiation and osteocyte activity. Sclerostin (SOST) and Dickkopf 1 (DKK1) are Wnt/β catenin pathway inhibitors. Genetic variability in the expression of SOST and DKK1 might be involved in the development of postmenopausal osteoporosis (OP).