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Colistin Resistance Mechanisms in Clinical Escherichia coli and Klebsiella spp. Isolates from the Western Cape of South Africa
Microbial Drug Resistance  (IF3.431),  Pub Date : 2021-09-09, DOI: 10.1089/mdr.2020.0479
Yolandi Snyman, Andrew Christopher Whitelaw, Sandra Reuter, Motlatji Reratilwe Bonnie Maloba, Mae Newton-Foot

Objectives: Colistin is a last-resort antibiotic for the treatment of carbapenem-resistant Gram-negative infections. Colistin resistance thus poses a threat to human health. Colistin resistance is most commonly encoded by mutations in chromosomal pmrA, pmrB, phoP, phoQ, ccrB, and mgrB genes, and the presence of plasmid-mediated mcr genes. This study describes colistin resistance mechanisms in clinical Enterobacterales isolates from the Western Cape, South Africa.