The COVID-19 pandemic has compelled university students to adapt to remote learning modalities resulting in increased of anxiety symptoms. This study explores levels of anxiety, and risk and protection factors among Social Work students at two universities in southern Spain. Thirty four percent were experiencing severe anxiety, and 28.5% mild to moderate, revealing that anxiety levels had increased significantly. Greater concern about academic situation and future economic scenario, living in an urban area and leave the habitual residence increased anxiety symptoms. By contrast, family income stability and higher social support from relatives reduced anxiety symptoms. These results support the planning of emotional support services for college students, as well as the incorporation in the study plans the acquisition of skills to live better in these conditions.