Example：10.1021/acsami.1c06204 or Chem. Rev., 2007, 107, 2411-2502
ALPHA-1 ANTITRYPSIN FOR CYSTIC FIBROSIS COMPLICATED BY SEVERE CYTOKINEMIC COVID-19 Journal of Cystic Fibrosis (IF5.482), Pub Date : 2021-01-01, DOI: 10.1016/j.jcf.2020.11.012 Oliver J McElvaney, Eoin O'Connor, Natalie L McEvoy, Daniel D Fraughan, Jennifer Clarke, Oisín F McElvaney, Cedric Gunaratnam, James O'Rourke, Gerard F Curley, Noel G McElvaney
BACKGROUND The clinical course of severe COVID-19 in cystic fibrosis (CF) is incompletely understood. We describe the use of alpha-1 antitrypsin (AAT) as a salvage therapy in a critically unwell patient with CF (PWCF) who developed COVID-19 while awaiting lung transplantation. METHODS IV AAT was administered at 120mg/kg/week for 4 consecutive weeks. Levels of interleukin (IL)-1β, IL-6, IL-8, and soluble TNF receptor 1 (sTNFR1) were assessed at regular intervals in plasma, with IL-1β, IL-6, IL-8 and neutrophil elastase (NE) activity measured in airway secretions. Levels were compared to baseline and historic severe exacerbation measurements. RESULTS Systemic and airway inflammatory markers were increased compared to both prior exacerbation and baseline levels, in particular IL-6, IL-1β and NE activity. Following each AAT dose, rapid decreases in each inflammatory parameter were observed. These were matched by marked clinical and radiographic improvement. CONCLUSIONS The results support further investigation of AAT as a COVID-19 therapeutic, and re-exploration of its use in CF.