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Example:10.1021/acsami.1c06204 or Chem. Rev., 2007, 107, 2411-2502
Prevalence and prognostic impact of nonischemic late gadolinium enhancement in stress cardiac magnetic resonance
Journal of Cardiovascular Medicine  (IF2.16),  Pub Date : 2020-12-01, DOI: 10.2459/jcm.0000000000001016
Chrysanthos Grigoratos, Ignazio Gueli, Christophe T. Arendt, Doris Leithner, Antonella Meloni, Cinzia Nugara, Andrea Barison, Giancarlo Todiere, Valentina O. Puntmann, Giuseppina Novo, Alessia Pepe, Michele Emdin, Eike Nagel, Giovanni Donato Aquaro


To assess the prevalence and prognostic significance of NI-LGE in patients undergoing stress-CMR.


Stress-CMR with either dipyridamole or adenosine was performed in 283 patients (228 men, 81%) including perfusion imaging, wall motion evaluation and LGE. Follow-up was completed in all enrolled patients (median time: 1850 days; interquartile range: 1225–2705 days). Composite endpoint included cardiac death, ventricular tachycardia, myocardial infarction, stroke, hospitalization for cardiac cause and coronary revascularization performed beyond 90 days from stress-CMR scans.


One hundred and twelve patients (40%) had negative LGE (no-LGE), 140 patients (49%) I-LGE and 31 patients (11%) NI-LGE. Twenty-five events occurred in the no-LGE group, 68 in I-LGE and 11 in the NI-LGE group. On survival curves, patients with NI-LGE had worse prognosis than patients with no-LGE regardless of the presence of inducible perfusion defects. No significant prognostic differences were found between I-LGE and NI-LGE.


NI-LGE can be detected in 11% of patients during stress-CMR providing a diagnosis of nonischemic cardiac disease. Patients with NI-LGE have worse prognosis than those with no-LGE.