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Cardiac fibroblast activation during myocardial infarction wound healing: Fibroblast polarization after MI.
Matrix Biology  (IF11.583),  Pub Date : 2020-05-21, DOI: 10.1016/j.matbio.2020.03.010
Michael J Daseke,Mavis A A Tenkorang,Upendra Chalise,Shelby R Konfrst,Merry L Lindsey

Cardiac wound healing after myocardial infarction (MI) evolves from pro-inflammatory to anti-inflammatory to reparative responses, and the cardiac fibroblast is a central player during the entire transition. The fibroblast mirrors changes seen in the left ventricle infarct by undergoing a continuum of polarization phenotypes that follow pro-inflammatory, anti-inflammatory, and pro-scar producing profiles. The development of each phenotype transition is contingent upon the MI environment into which the fibroblast enters. In this mini-review, we summarize our current knowledge regarding cardiac fibroblast activation during MI and highlight key areas where gaps remain.