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A water-stable Cu(II)-based coordination polymer for clinical nursing effect on schizophrenia by inhibiting over-activity of the dopaminergic neurons
Supramolecular Chemistry  (IF1.688),  Pub Date : 2020-03-11, DOI: 10.1080/10610278.2020.1739285
Suying Tian, Dongmei Tian

ABSTRACT In this study, we use two methyl-substituted organic ligands 5-methylisophthalic acid (H2mica) and 1,3-bis(5,6-dimethylbenzimidazol-1-yl)propane (L) as the co-linkers to produce a water-stable Cu(II)-containing coordination polymer {[Cu(mica)(L)2]·H2O}n (1) under the solvothermal condition. Furthermore, the protective effect of 1 on schizophrenia mice was evaluated in vivo. Firstly, the relative expression level of the dopamine transporter in the mesencephalic limbic system of schizophrenia was detected with RT-PCR. Then, the content of the dopamine released by the mesencephalic limbic system was measured with ELISA assay. Annexin V-FITC/PI apoptosis was used to detect the percentage of the apoptotic dopaminergic neuron. The relative expression of the Wnt1-Nkx2.2 was measured with RT-PCR. Graphical abstract