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Success of Weekly Adalimumab in Refractory Ocular Inflammatory Disease.
Ophthalmology  (IF12.079),  Pub Date : 2020-04-17, DOI: 10.1016/j.ophtha.2020.04.009
Jennifer Lee,Anjum F Koreishi,Katelyn B Zumpf,Caroline L Minkus,Debra A Goldstein

Purpose

Evaluate the efficacy of weekly adalimumab (ADA) in patients with non-infectious ocular inflammation who failed standard every other week (EOW) dosing.

Design

Single-center, retrospective, study.

Subjects

Patients with uncontrolled inflammation on ADA EOW who were escalated to weekly dosing.

Methods

Chart review conducted at Northwestern University, January 2012 to April 2019.

Outcome: Number of treatment successes on weekly ADA at 6 and 12 months.

Results

Fourteen of 25 patients (56%) achieved disease control at 6 months; no additional failures occurred at 12 months.

Conclusion

Weekly ADA is a reasonable treatment option in patients with recalcitrant inflammation on standard dosing.