Example：10.1021/acsami.1c06204 or Chem. Rev., 2007, 107, 2411-2502
Adamantane/Cucurbituril: A Potential Pretargeted Imaging Strategy in Immuno-PET. Molecular Imaging (IF4.488), Pub Date : 2018-10-26, DOI: 10.1177/1536012118799838 Martin G Strebl,Jane Yang,Lyle Isaacs,Jacob M Hooker
Positron emission tomography (PET) imaging with biological macromolecules greatly expands the possibilities of molecular imaging. There are, however, practical aspects limiting the potential of the approach, including the dosimetric consequences of the slow kinetics of radiolabeled biomacromolecules. Pretargeting strategies have led to impactful improvements in the field but are themselves limited by shortcomings of available bioconjugation methodology. We report our initial findings concerning the suitability of the adamantane/cucurbituril system for pretargeted immuno-PET imaging and provide proof-of-concept PET/computed tomography imaging experiments to establish the stability and rapid formation of host-guest complexes in vivo. The adamantane/cucurbituril system itself without antibody conjugation has shown remarkably fast association kinetics and clearance in vivo. We further demonstrate the modulation of biodistribution achievable by cucurbituril complexation with relevance for pharmaceutical formulation as well as the radiosynthetic access to relevant reporter molecules labeled with 11C or 18F. This work, an early proof-of-concept, supports the notion that the adamantane/cucurbituril system warrants further exploration in pretargeted PET imaging applications.